IKZF2

Across TCGA pan-cancer cohorts, IKZF2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IKZF2 data layer compared with 9 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IKZF2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IKZF2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LGG are the cancer types where IKZF2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.701	0.504	<.001	67	view →
SKCM	OS	Tertile	All	0.400	0.251	<.001	53	view →
LGG	OS	Median	All	0.381	0.530	<.001	46	view →
KIRC	DFS	Quartile	All	0.804	0.505	<.001	45	view →
ACC	DFS	Median	III,IV	0.475	0.186	.006	36	view →
BRCA	OS	Tertile	IV	0.953	0.407	.003	33	view →
THYM	OS	Median	All	1.000	0.743	.001	21	view →
THCA	OS	Tertile	III,IV	1.000	0.712	.006	21	view →
CHOL	DFS	Median	II,III,IV	0.634	0.117	.015	18	view →
PRAD	DFS	Median	All	0.955	0.911	.008	12	view →
LIHC	OS	Median	All	0.824	0.712	.045	6	view →
UVM	DFS	Median	III,IV	0.220	0.664	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IKZF2–HNSC (DFS)

Open the HNSC breakdown →