IGKV3-20

Across TCGA patient cohorts, IGKV3-20 protein abundance is significantly associated with the RNA expression of many other genes, with 16,211 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGKV3-20-associated genes across cancer lineages are IGHV1-69, IGKV3D-20, and IGHV4-34. Each is linked with IGKV3-20 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGKV3-20-to-partner and partner-to-IGKV3-20 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV3-20 versus IGHV1-69 in OV, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV3-20→partner) and Y-score (partner→IGKV3-20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IGHV1-69 →	+3.177	+1.451	<.001	<.001	3	8
BRCA	IGKV3D-20 →	+2.676	+0.664	<.001	<.001	3	8
BRCA	IGHV4-34 →	+2.445	+0.610	<.001	<.001	3	8
BRCA	SLAMF7 →	+1.284	+0.607	<.001	<.001	3	7
BRCA	P2RX1 →	+0.820	+0.668	<.001	<.001	3	7
BRCA	LAX1 →	+1.088	+0.608	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,211 associations by consensus.

IGKV3-20 vs IGHV1-69 — OV

Explore this scatter interactively →