IGKV3-20

Across TCGA pan-cancer cohorts, IGKV3-20 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGKV3-20 data layer compared with 3 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV3-20 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV3-20 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV3-20 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.751	0.618	<.001	143	view →
SKCM	DFS	Median	All	0.675	0.557	<.001	112	view →
BRCA	DFS	Median	All	0.970	0.927	<.001	47	view →
COAD	DFS	Median	All	0.621	0.442	.003	39	view →
OV	DFS	Tertile	III,IV	0.418	0.320	.006	38	view →
SARC	OS	Median	All	0.897	0.774	.002	34	view →
UCEC	DFS	Tertile	III,IV	0.669	0.372	.007	26	view →
LIHC	DFS	Median	All	0.390	0.209	.007	21	view →
GBM	OS	Quartile	All	0.250	0.614	.002	20	view →
KIRP	DFS	Median	All	0.589	0.888	.003	20	view →
UCS	OS	Quartile	II,III,IV	0.688	0.255	.028	18	view →
CHOL	DFS	Quartile	All	0.812	0.262	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGKV3-20–HNSC (DFS)

Open the HNSC breakdown →