IGKV3-20

Across TCGA pan-cancer cohorts, IGKV3-20 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGKV3-20’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV3-20 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV3-20 is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.

COAD, LUAD, and LIHC are the cancer types where IGKV3-20 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV3-20 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−4.380	<.001	11	view →
LUAD	Female	II,III,IV	+2.652	<.001	9	view →
LIHC	Male	All	−3.362	<.001	6	view →
KIRC	Male	All	+2.020	<.001	4	view →
KICH	All	II,III,IV	−2.354	.012	3	view →
READ	All	All	−3.865	.001	2	view →
BRCA	Female	All	−0.654	.039	2	view →
HNSC	All	III,IV	+1.679	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGKV3-20–COAD

Open the COAD breakdown →