IGKV2OR2-1

Across TCGA patient cohorts, IGKV2OR2-1 RNA expression is significantly associated with the RNA expression of many other genes, with 5,376 significant associations in total. PAAD shows the largest number of these associations.

The most reproducible IGKV2OR2-1-associated genes across cancer lineages are IGKV1D-39, IGKV1OR2-6, and IGHV1OR21-1. Each is linked with IGKV2OR2-1 in more than 31 cancer types. Because this analysis shows association rather than direction, both IGKV2OR2-1-to-partner and partner-to-IGKV2OR2-1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV2OR2-1 versus IGKV1D-39 in ESCA, with a Pearson correlation of 0.52.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2OR2-1→partner) and Y-score (partner→IGKV2OR2-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	IGKV1D-39 →	+2.439	+0.285	<.001	<.001	3	32
LUSC	IGKV1OR2-6 →	+2.200	+1.217	<.001	<.001	3	31
LUSC	IGHV1OR21-1 →	+1.791	+1.165	<.001	<.001	3	31
THCA	IGHV3-41 →	+1.629	+0.767	<.001	<.001	3	31
THCA	IGHJ2 →	+3.655	+0.745	<.001	<.001	3	31
UVM	IGHV3-13 →	+4.173	+0.060	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,376 associations by consensus.

IGKV2OR2-1 vs IGKV1D-39 — ESCA

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