IGKV2OR2-1

Across TCGA pan-cancer cohorts, IGKV2OR2-1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGKV2OR2-1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV2OR2-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV2OR2-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

HNSC, OV, and READ are the cancer types where IGKV2OR2-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.410	0.260	<.001	144	view →
OV	DFS	Tertile	II,III,IV	0.614	0.515	.009	58	view →
READ	DFS	Tertile	III,IV	1.000	0.615	<.001	53	view →
GBM	OS	Tertile	All	0.058	0.416	<.001	36	view →
SKCM	OS	Tertile	All	0.442	0.292	.004	30	view →
LGG	DFS	Tertile	All	0.468	0.836	<.001	30	view →
BLCA	DFS	Median	IV	0.532	0.195	.004	23	view →
UCEC	DFS	Tertile	All	0.841	0.917	.007	22	view →
CHOL	DFS	Quartile	All	0.794	0.311	.018	12	view →
KIRP	OS	Tertile	All	0.548	0.813	.032	12	view →
COAD	OS	Median	All	0.671	0.548	.023	8	view →
KIRC	DFS	Median	IV	0.726	0.540	.027	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGKV2OR2-1–HNSC (DFS)

Open the HNSC breakdown →