IGKV2D-38

Q-omics provides the consensus-scored IGKV2D-38 profile across patient tissues and cancer cell-line models. IGKV2D-38 expression is associated with patient survival in 4 of 34 cancer types, with the highest sampling consensus in LUSC. Additionally, IGKV2D-38 RNA expression shows 2,381 significant gene co-expression associations, with the highest sampling consensus in HNSC. Together, these results highlight LUSC, and HNSC as cancer lineages where IGKV2D-38 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Survival associations

This table summarizes IGKV2D-38 survival associations across molecular data types. IGKV2D-38 RNA expression shows survival associations in the most cancer types (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

IGKV2D-38 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	4	LUSC (36)	view →

This table ranks reproducible IGKV2D-38 RNA expression–survival associations across cancer types. High IGKV2D-38 expression shows unfavorable associations in LUSC, BLCA and SKCM, but favorable associations in HNSC. The LUSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify LUSC as the clearest survival context for IGKV2D-38 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	All	0.402	0.672	.002	36	view →
HNSC	DFS	Tertile	All	0.968	0.685	.004	33	view →
BLCA	OS	Tertile	All	0.197	0.720	.004	27	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	27	view →

Pink = unfavorable, green = favorable. all 4 lineages →

IGKV2D-38-LUSC (OS)

Explore this curve interactively →