IGKV2D-38

Across TCGA patient cohorts, IGKV2D-38 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,796 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV2D-38-associated GO terms across cancer lineages are B cell mediated immunity, Immunoglobulin production, and Positive regulation of interleukin-2 production. Each is linked with IGKV2D-38 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGKV2D-38-to-partner and partner-to-IGKV2D-38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGKV2D-38-low versus IGKV2D-38-high in HNSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-38→partner) and Y-score (partner→IGKV2D-38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	B cell mediated immunity →	+0.082	+0.031	<.001	<.001	3	5
HNSC	Immunoglobulin production →	+0.069	+0.032	<.001	<.001	3	5
SKCM	Positive regulation of interleukin-2 production →	+0.063	+0.033	.002	.006	3	4
HNSC	Cellular extravasation →	+0.056	+0.026	<.001	<.001	3	4
BRCA	Microglia differentiation →	+0.043	+0.010	<.001	.001	3	3
HNSC	Leukocyte homeostasis →	+0.049	+0.027	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,796 associations by consensus.

B cell mediated immunity by IGKV2D-38 expression — HNSC

Explore this box plot interactively →