IGKV2D-38

Across TCGA pan-cancer cohorts, IGKV2D-38 RNA is linked to patient survival in 4 of 34 cancer types, making it the most broadly survival-associated IGKV2D-38 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher IGKV2D-38 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV2D-38 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUSC, HNSC, and SKCM are the cancer types where IGKV2D-38 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	All	0.402	0.672	.002	36	view →
HNSC	DFS	Tertile	All	0.968	0.685	.004	33	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	27	view →
BLCA	OS	Tertile	All	0.197	0.720	.004	27	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IGKV2D-38–LUSC (OS)

Open the LUSC breakdown →