Across TCGA patient cohorts, IGKV2D-26 protein abundance is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV2D-26-associated genes across cancer lineages are ILDR1, DEFB4A, and MGAT4D. Each is linked with IGKV2D-26 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2D-26-to-partner and partner-to-IGKV2D-26 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-26→partner) and Y-score (partner→IGKV2D-26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ILDR1 →	+1.106	+1.146	.005	.007	3	1
LSCC	DEFB4A →	+2.483	+2.654	<.001	.005	3	1
LSCC	MGAT4D →	+0.050	+2.634	<.001	.005	3	1
LSCC	RNU6-348P →	+0.723	+2.454	<.001	.001	3	1
LSCC	DBIP1 →	+0.770	+2.533	<.001	.003	3	1
LSCC	NACAP7 →	+0.156	+2.454	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

IGKV2D-26 survival (RNA) · tumor vs normal (RNA) · all IGKV2D-26 data types