Across TCGA pan-cancer cohorts, IGKV2D-26 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGKV2D-26’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV2D-26 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV2D-26 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, LUAD, and STAD are the cancer types where IGKV2D-26 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2D-26 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−0.498	.002	5	view →
LUAD	All	All	+0.227	<.001	5	view →
STAD	Male	IV	−2.739	.003	4	view →
KIRC	All	All	+0.084	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: IGKV2D-26 RNA expression & survival · all IGKV2D-26 data types