IGKV2D-23

Across TCGA patient cohorts, IGKV2D-23 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,248 significant associations in total. THCA shows the largest number of these associations.

The most reproducible IGKV2D-23-associated GO terms across cancer lineages are Immunoglobulin production, Regulation of alpha-beta T cell activation, and B cell mediated immunity. Each is linked with IGKV2D-23 in more than 7 cancer types. Because this analysis shows association rather than direction, both IGKV2D-23-to-partner and partner-to-IGKV2D-23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Immunoglobulin production grouped by IGKV2D-23-low versus IGKV2D-23-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2D-23→partner) and Y-score (partner→IGKV2D-23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Immunoglobulin production →	+0.097	+0.017	<.001	<.001	3	8
THCA	Regulation of alpha-beta T cell activation →	+0.051	+0.017	<.001	<.001	3	6
THCA	B cell mediated immunity →	+0.130	+0.017	<.001	<.001	3	6
THCA	Regulation of leukocyte apoptotic process →	+0.052	+0.027	<.001	<.001	3	5
THCA	Regulation of CD4-positive, alpha-beta T cell activation →	+0.046	+0.016	<.001	<.001	3	5
SKCM	Lymphocyte activation involved in immune response →	+0.039	+0.013	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,248 associations by consensus.

Immunoglobulin production by IGKV2D-23 expression — THCA

Explore this box plot interactively →