IGKV2D-23

Across TCGA pan-cancer cohorts, IGKV2D-23 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated IGKV2D-23 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher IGKV2D-23 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2D-23 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

BLCA, UCEC, and STAD are the cancer types where IGKV2D-23 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	III,IV	0.960	0.638	.010	54	view →
UCEC	DFS	Tertile	All	0.457	0.899	<.001	54	view →
STAD	DFS	Tertile	All	0.458	0.667	.007	36	view →
COAD	DFS	Tertile	II,III,IV	0.086	0.747	<.001	27	view →
SKCM	DFS	Tertile	III,IV	0.859	0.232	.008	24	view →
KIRC	DFS	Tertile	IV	0.100	0.631	.024	18	view →
LAML	DFS	Tertile	All	0.616	0.316	.024	12	view →
LUSC	OS	Tertile	II,III,IV	0.154	0.416	.033	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

IGKV2D-23–BLCA (OS)

Open the BLCA breakdown →