IGKV2-29

Across TCGA patient cohorts, IGKV2-29 mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV2-29-associated genes across cancer lineages are SPCS2P2, RPL7P40, and MIR412. Each is linked with IGKV2-29 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV2-29-to-partner and partner-to-IGKV2-29 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPCS2P2 grouped by IGKV2-29-low versus IGKV2-29-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-29→partner) and Y-score (partner→IGKV2-29) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SPCS2P2 →	+0.135	+5.594	<.001	.004	3	2
SKCM	RPL7P40 →	+0.060	+5.292	.002	.006	3	2
UCEC	MIR412 →	+0.621	+8.066	<.001	.007	3	1
LUAD	SSX7 →	+0.093	+5.631	<.001	.004	3	1
LUAD	COX6A1P3 →	+0.170	+4.990	<.001	.009	3	1
LUAD	RN7SKP169 →	+0.560	+5.631	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

SPCS2P2 by IGKV2-29 expression — SKCM

Explore this box plot interactively →