IGKV2-29

Across TCGA pan-cancer cohorts, IGKV2-29 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated IGKV2-29 data layer compared with 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGKV2-29 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV2-29 expression acts as an unfavorable survival marker, although some lineages such as UCEC and OV show a favorable association.

UCEC, OV, and BRCA are the cancer types where IGKV2-29 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.695	0.430	.002	42	view →
OV	DFS	Quartile	All	0.429	0.330	.009	30	view →
BRCA	DFS	Median	All	0.964	0.932	.009	26	view →
CHOL	DFS	Median	All	0.759	0.123	.004	24	view →
LUAD	DFS	Tertile	III,IV	0.796	0.548	.002	21	view →
LIHC	DFS	Tertile	All	0.559	0.372	<.001	19	view →
GBM	DFS	Tertile	All	0.166	0.321	.026	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
SKCM	DFS	Tertile	All	0.838	0.696	.006	15	view →
DLBC	DFS	Median	All	0.347	0.858	.007	12	view →
CESC	OS	Tertile	All	0.841	0.687	.007	12	view →
KIRC	DFS	Quartile	III,IV	0.736	0.578	.038	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

IGKV2-29–UCEC (OS)

Open the UCEC breakdown →