IGKV2-29

Across TCGA pan-cancer cohorts, IGKV2-29 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGKV2-29’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV2-29 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV2-29 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGKV2-29 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV2-29 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−1.309	.008	4	view →
LUAD	All	All	+1.246	.001	3	view →
KIRC	Male	All	+0.623	.015	2	view →
STAD	All	IV	−3.486	.026	1	view →
READ	All	All	−2.140	.046	1	view →
LIHC	Male	All	−0.749	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGKV2-29–COAD

Open the COAD breakdown →