IGKV1OR2-6

Across TCGA patient cohorts, IGKV1OR2-6 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,079 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV1OR2-6-associated GO terms across cancer lineages are Antibacterial humoral response, B cell receptor signaling pathway, and Complement activation, classical pathway. Each is linked with IGKV1OR2-6 in more than 31 cancer types. Because this analysis shows association rather than direction, both IGKV1OR2-6-to-partner and partner-to-IGKV1OR2-6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antibacterial humoral response grouped by IGKV1OR2-6-low versus IGKV1OR2-6-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1OR2-6→partner) and Y-score (partner→IGKV1OR2-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Antibacterial humoral response →	+0.169	+1.926	<.001	<.001	3	32
CHOL	B cell receptor signaling pathway →	+0.119	+1.778	<.001	<.001	3	31
THCA	Complement activation, classical pathway →	+0.200	+1.837	<.001	<.001	3	31
ESCA	B cell mediated immunity →	+0.109	+1.381	<.001	<.001	3	31
PAAD	Respiratory burst →	+0.085	+1.282	<.001	<.001	3	30
CHOL	Positive regulation of tumor necrosis factor superfamily cytokine production →	+0.066	+2.148	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,079 associations by consensus.

Antibacterial humoral response by IGKV1OR2-6 expression — THCA

Explore this box plot interactively →