IGKV1OR2-6

Across TCGA pan-cancer cohorts, IGKV1OR2-6 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGKV1OR2-6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1OR2-6 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1OR2-6 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGKV1OR2-6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1OR2-6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−3.192	<.001	12	view →
LUAD	Female	All	+1.602	<.001	6	view →
BRCA	Female	II,III,IV	−0.724	<.001	6	view →
KIRC	All	All	+0.482	.003	4	view →
READ	Female	All	−2.932	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IGKV1OR2-6–COAD

Open the COAD breakdown →