IGKV1OR2-6

Across TCGA pan-cancer cohorts, IGKV1OR2-6 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGKV1OR2-6 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1OR2-6 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV1OR2-6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV1OR2-6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.759	0.612	<.001	131	view →
SKCM	OS	Tertile	All	0.415	0.281	<.001	114	view →
BRCA	DFS	Tertile	All	0.591	0.482	<.001	69	view →
UVM	DFS	Tertile	All	0.503	0.781	.026	45	view →
KIRP	OS	Quartile	All	0.471	0.783	.001	30	view →
COAD	DFS	Median	All	0.751	0.636	.005	28	view →
PAAD	OS	Quartile	II,III,IV	0.828	0.486	.002	21	view →
BLCA	OS	Median	III,IV	0.405	0.173	.017	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
LUAD	OS	Median	All	0.451	0.285	.018	18	view →
ESCA	DFS	Quartile	II,III,IV	0.601	0.362	.004	15	view →
LUSC	DFS	Median	III,IV	0.658	0.427	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGKV1OR2-6–HNSC (OS)

Open the HNSC breakdown →