IGKV1D-43

Across TCGA patient cohorts, IGKV1D-43 mutation is significantly associated with the RNA expression of many other genes, with 351 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV1D-43-associated genes across cancer lineages are RPL32P12, RNU6-866P, and SNORD90. Each is linked with IGKV1D-43 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-43-to-partner and partner-to-IGKV1D-43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL32P12 grouped by IGKV1D-43-low versus IGKV1D-43-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-43→partner) and Y-score (partner→IGKV1D-43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL32P12 →	+0.190	+3.619	.002	.008	3	2
SKCM	RNU6-866P →	+0.371	+3.353	<.001	.003	3	2
UCEC	SNORD90 →	+0.473	+2.670	<.001	.009	3	2
HNSC	RNU6ATAC34P →	+0.300	+3.355	<.001	.008	3	2
HNSC	RNU6-705P →	+1.091	+4.090	<.001	.001	3	2
HNSC	RNU6-677P →	+0.314	+3.202	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 351 associations by consensus.

RPL32P12 by IGKV1D-43 expression — SKCM

Explore this box plot interactively →