IGKV1D-43

Across TCGA pan-cancer cohorts, IGKV1D-43 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGKV1D-43 data layer compared with 3 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IGKV1D-43 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1D-43 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and UVM are the cancer types where IGKV1D-43 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.685	0.547	<.001	135	view →
HNSC	OS	Tertile	All	0.837	0.665	<.001	125	view →
UVM	DFS	Tertile	All	0.079	0.746	<.001	99	view →
UCEC	OS	Median	III,IV	0.729	0.417	<.001	60	view →
BRCA	OS	Quartile	All	0.649	0.506	<.001	46	view →
SARC	DFS	Tertile	All	0.632	0.451	.001	30	view →
LUAD	DFS	Tertile	All	0.742	0.616	.005	26	view →
KIRP	OS	Quartile	All	0.588	0.812	.004	23	view →
STAD	DFS	Quartile	II,III,IV	0.402	0.649	.014	22	view →
COAD	DFS	Median	All	0.757	0.627	.001	22	view →
PAAD	DFS	Median	II,III,IV	0.539	0.358	.001	19	view →
MESO	OS	Tertile	All	0.791	0.282	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGKV1D-43–SKCM (DFS)

Open the SKCM breakdown →