IGKV1D-43

Across TCGA pan-cancer cohorts, IGKV1D-43 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IGKV1D-43’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1D-43 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1D-43 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGKV1D-43 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1D-43 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.146	<.001	7	view →
LUAD	Female	All	+1.291	<.001	7	view →
BRCA	Female	II,III,IV	−0.454	.002	6	view →
KIRC	Male	All	+0.499	<.001	4	view →
KICH	All	All	−0.380	.010	4	view →
KIRP	Female	II,III,IV	−0.318	.045	3	view →
LIHC	Male	All	−0.227	.010	2	view →
STAD	All	IV	−3.326	.043	1	view →
READ	All	All	−1.298	.038	1	view →
LUSC	Female	III,IV	+0.555	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IGKV1D-43–COAD

Open the COAD breakdown →