IGKV1-9

Across TCGA patient cohorts, IGKV1-9 RNA expression is significantly associated with the RNA expression of many other genes, with 9,980 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible IGKV1-9-associated genes across cancer lineages are IGKV3-7, IGKV2D-29, and IGKV1-5. Each is linked with IGKV1-9 in more than 32 cancer types. Because this analysis shows association rather than direction, both IGKV1-9-to-partner and partner-to-IGKV1-9 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV1-9 versus IGKV3-7 in HNSC, with a Pearson correlation of 0.81.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-9→partner) and Y-score (partner→IGKV1-9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IGKV3-7 →	+2.831	+4.145	<.001	<.001	3	33
HNSC	IGKV2D-29 →	+3.540	+3.937	<.001	<.001	3	33
THCA	IGKV1-5 →	+5.731	+5.059	<.001	<.001	3	33
THCA	IGKV3-15 →	+5.488	+5.058	<.001	<.001	3	33
THCA	IGKV1-27 →	+4.464	+4.877	<.001	<.001	3	33
TGCT	IGKV2D-40 →	+2.960	+3.019	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,980 associations by consensus.

IGKV1-9 vs IGKV3-7 — HNSC

Explore this scatter interactively →