IGKV1-9

Across TCGA pan-cancer cohorts, IGKV1-9 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGKV1-9 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1-9 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV1-9 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV1-9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.809	0.692	<.001	143	view →
SKCM	OS	Tertile	All	0.447	0.280	<.001	121	view →
BRCA	DFS	Median	All	0.971	0.926	<.001	84	view →
UCEC	OS	Tertile	III,IV	0.725	0.390	.003	52	view →
CESC	DFS	Median	All	0.791	0.681	.015	34	view →
SARC	OS	Quartile	All	0.975	0.798	.009	21	view →
UVM	DFS	Tertile	II,III,IV	0.322	0.715	.003	20	view →
TGCT	DFS	Median	All	0.913	0.750	.007	18	view →
KIRP	DFS	Quartile	All	0.490	0.914	.010	17	view →
KIRC	OS	Median	All	0.762	0.845	.003	16	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	15	view →
LIHC	DFS	Median	III,IV	0.596	0.202	<.001	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGKV1-9–HNSC (OS)

Open the HNSC breakdown →