IGKV1-9

Across TCGA pan-cancer cohorts, IGKV1-9 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGKV1-9’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1-9 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1-9 is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.

COAD, LUAD, and LIHC are the cancer types where IGKV1-9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1-9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−2.543	<.001	11	view →
LUAD	Female	All	+1.954	<.001	7	view →
LIHC	Male	All	−2.536	<.001	6	view →
BRCA	Female	II,III,IV	−1.475	<.001	6	view →
KIRC	Male	All	+1.817	<.001	5	view →
READ	All	All	−3.758	.002	2	view →
KICH	All	All	−1.289	.036	2	view →
HNSC	Female	III,IV	+2.777	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGKV1-9–COAD

Open the COAD breakdown →