IGKV1-6

Across TCGA patient cohorts, IGKV1-6 protein abundance is significantly associated with the RNA expression of many other genes, with 1,327 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGKV1-6-associated genes across cancer lineages are NEK11, RAB2B, and LENEP. Each is linked with IGKV1-6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-6-to-partner and partner-to-IGKV1-6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV1-6 versus NEK11 in PDAC, with a Pearson correlation of -0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-6→partner) and Y-score (partner→IGKV1-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NEK11 →	-0.767	-1.533	.004	.003	3	2
PDAC	RAB2B →	-0.433	-1.138	.002	.006	3	2
LUAD	LENEP →	-0.823	-0.674	<.001	.006	3	2
PDAC	MAPK1 →	-0.322	-1.282	.004	.005	3	1
PDAC	DDX17 →	-0.538	-1.138	<.001	.006	3	1
PDAC	CBY1 →	-0.667	-1.862	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,327 associations by consensus.

IGKV1-6 vs NEK11 — PDAC

Explore this scatter interactively →