IGKV1-6

Across TCGA pan-cancer cohorts, IGKV1-6 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IGKV1-6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1-6 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1-6 is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.

COAD, LUAD, and LIHC are the cancer types where IGKV1-6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1-6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−4.166	<.001	9	view →
LUAD	Female	All	+1.975	<.001	9	view →
LIHC	Male	All	−2.773	<.001	6	view →
BRCA	Female	II,III,IV	−1.160	<.001	6	view →
KIRC	Male	All	+1.380	<.001	4	view →
READ	All	All	−2.966	<.001	3	view →
KICH	All	All	−1.349	.013	3	view →
ESCA	All	II,III,IV	+4.515	.008	2	view →
UCEC	All	IV	+1.750	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IGKV1-6–COAD

Open the COAD breakdown →