IGKV1-6

Across TCGA pan-cancer cohorts, IGKV1-6 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGKV1-6 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1-6 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1-6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV1-6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.668	0.540	<.001	144	view →
SKCM	OS	Median	All	0.407	0.277	<.001	111	view →
BRCA	DFS	Median	All	0.969	0.928	<.001	81	view →
UCEC	OS	Median	III,IV	0.705	0.422	.003	52	view →
UCS	OS	Tertile	II,III,IV	0.691	0.261	.005	44	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	21	view →
ACC	DFS	Tertile	All	0.773	0.495	.008	21	view →
SARC	OS	Median	All	0.820	0.669	.002	21	view →
MESO	OS	Quartile	II,III,IV	0.783	0.467	.011	20	view →
LIHC	DFS	Median	III,IV	0.578	0.229	.002	17	view →
GBM	OS	Quartile	All	0.207	0.496	.004	16	view →
UVM	DFS	Tertile	All	0.566	0.803	.027	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGKV1-6–HNSC (DFS)

Open the HNSC breakdown →