IGKV1-6

Across TCGA patient cohorts, IGKV1-6 mutation is significantly associated with the RNA expression of many other genes, with 238 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV1-6-associated genes across cancer lineages are H2BU2P, MIR181A2, and MIR3198-1. Each is linked with IGKV1-6 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-6-to-partner and partner-to-IGKV1-6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BU2P grouped by IGKV1-6-low versus IGKV1-6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-6→partner) and Y-score (partner→IGKV1-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	H2BU2P →	+0.440	+4.029	<.001	<.001	3	2
LUSC	MIR181A2 →	+0.423	+3.001	<.001	.001	3	2
UCEC	MIR3198-1 →	+0.833	+3.831	.004	.009	3	2
LUSC	MIR8070 →	+0.782	+2.986	<.001	.001	3	2
PRAD	RNU6-918P →	+0.381	+5.166	<.001	.007	3	2
PRAD	BCAR1P2 →	+0.077	+5.166	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 238 associations by consensus.

H2BU2P by IGKV1-6 expression — LUSC

Explore this box plot interactively →