IGHV8-51-1

Across TCGA patient cohorts, IGHV8-51-1 RNA expression is significantly associated with the RNA expression of many other genes, with 6,887 significant associations in total. THYM shows the largest number of these associations.

The most reproducible IGHV8-51-1-associated genes across cancer lineages are IGHV3-25, IGHV7-56, and IGHV3OR16-6. Each is linked with IGHV8-51-1 in more than 29 cancer types. Because this analysis shows association rather than direction, both IGHV8-51-1-to-partner and partner-to-IGHV8-51-1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV8-51-1 versus IGHV3-25 in LUAD, with a Pearson correlation of 0.70.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV8-51-1→partner) and Y-score (partner→IGHV8-51-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IGHV3-25 →	+1.363	+0.922	<.001	<.001	3	30
THCA	IGHV7-56 →	+1.531	+0.482	<.001	<.001	3	29
LUAD	IGHV3OR16-6 →	+1.617	+0.899	<.001	<.001	3	28
READ	IGLJ2 →	+2.159	+0.420	<.001	<.001	3	28
THCA	IGHV3-35 →	+2.145	+0.442	<.001	<.001	3	28
HNSC	IGHV1-58 →	+3.144	+0.569	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,887 associations by consensus.

IGHV8-51-1 vs IGHV3-25 — LUAD

Explore this scatter interactively →