IGHV8-51-1

Across TCGA pan-cancer cohorts, IGHV8-51-1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated IGHV8-51-1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV8-51-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV8-51-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and KIRP are the cancer types where IGHV8-51-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.677	0.549	<.001	144	view →
SKCM	OS	Tertile	All	0.448	0.289	<.001	116	view →
KIRP	DFS	Tertile	II,III,IV	0.158	0.734	.006	45	view →
BRCA	OS	Tertile	All	0.978	0.954	.005	31	view →
UCEC	OS	Tertile	III,IV	0.915	0.802	.032	18	view →
LGG	OS	Tertile	All	0.103	0.890	<.001	18	view →
PAAD	OS	Tertile	II,III,IV	0.708	0.447	.003	16	view →
READ	DFS	Median	IV	0.794	0.325	<.001	16	view →
KIRC	DFS	Tertile	II,III,IV	0.334	0.560	.028	14	view →
LUAD	DFS	Median	IV	1.000	0.709	.022	14	view →
STAD	OS	Tertile	IV	0.855	0.323	.023	6	view →
COAD	OS	Tertile	III,IV	0.845	0.596	.029	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

IGHV8-51-1–HNSC (DFS)

Open the HNSC breakdown →