IGHV8-51-1

Across TCGA pan-cancer cohorts, IGHV8-51-1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHV8-51-1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV8-51-1 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV8-51-1 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and LUAD are the cancer types where IGHV8-51-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV8-51-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−0.885	<.001	9	view →
READ	All	All	−0.828	<.001	5	view →
LUAD	Female	All	+0.657	<.001	5	view →
KIRC	All	All	+0.134	.001	3	view →
ESCA	All	II,III,IV	+0.345	.024	2	view →
BRCA	Female	All	−0.101	.047	2	view →
STAD	Male	IV	−2.235	.011	1	view →
KICH	All	All	−0.112	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGHV8-51-1–COAD

Open the COAD breakdown →