IGHV4-4

Across TCGA patient cohorts, IGHV4-4 protein abundance is significantly associated with the RNA expression of many other genes, with 3,390 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGHV4-4-associated genes across cancer lineages are IGHV1-3, IRF4, and P2RY8. Each is linked with IGHV4-4 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHV4-4-to-partner and partner-to-IGHV4-4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV4-4 versus IGHV1-3 in HNSC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-4→partner) and Y-score (partner→IGHV4-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IGHV1-3 →	+3.284	+1.134	<.001	<.001	3	7
UCEC	IRF4 →	+1.324	+1.233	<.001	<.001	3	4
GBM	P2RY8 →	+0.721	+0.978	.001	.001	3	4
LSCC	IGHD2-15 →	+1.672	+0.834	<.001	.001	3	4
UCEC	FAM30A →	+0.841	+1.484	<.001	<.001	3	4
HNSC	MIR4539 →	+1.081	+0.586	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,390 associations by consensus.

IGHV4-4 vs IGHV1-3 — HNSC

Explore this scatter interactively →