IGHV4-4

Across TCGA pan-cancer cohorts, IGHV4-4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated IGHV4-4 data layer compared with 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV4-4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV4-4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGHV4-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.765	0.626	<.001	145	view →
SKCM	OS	Median	All	0.426	0.273	<.001	93	view →
BRCA	DFS	Tertile	All	0.969	0.924	.006	38	view →
GBM	OS	Tertile	All	0.255	0.468	.009	24	view →
CESC	OS	Tertile	III,IV	0.674	0.307	.013	24	view →
UVM	DFS	Quartile	All	0.547	0.784	.031	22	view →
CHOL	DFS	Median	All	0.762	0.122	.003	15	view →
SARC	DFS	Tertile	All	0.685	0.436	.001	15	view →
KICH	DFS	Tertile	II,III,IV	0.624	0.933	.009	12	view →
UCEC	DFS	Median	All	0.861	0.915	.009	12	view →
KIRP	OS	Quartile	II,III,IV	0.704	0.886	.027	11	view →
LUAD	OS	Tertile	III,IV	0.682	0.353	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

IGHV4-4–HNSC (DFS)

Open the HNSC breakdown →