IGHV4-4

Across TCGA pan-cancer cohorts, IGHV4-4 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGHV4-4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV4-4 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV4-4 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHV4-4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV4-4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−2.920	<.001	10	view →
LUAD	Female	II,III,IV	+2.901	<.001	9	view →
KIRC	Male	All	+0.806	<.001	4	view →
READ	All	All	−3.036	.003	2	view →
HNSC	All	III,IV	+1.259	.025	2	view →
LIHC	Male	All	−0.532	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGHV4-4–COAD

Open the COAD breakdown →