IGHV3OR16-8

Across TCGA patient cohorts, IGHV3OR16-8 mutation is significantly associated with the RNA expression of many other genes, with 223 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3OR16-8-associated genes across cancer lineages are LINC01318, PINCR, and TPM4P1. Each is linked with IGHV3OR16-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3OR16-8-to-partner and partner-to-IGHV3OR16-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01318 grouped by IGHV3OR16-8-low versus IGHV3OR16-8-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3OR16-8→partner) and Y-score (partner→IGHV3OR16-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LINC01318 →	+0.075	+5.368	.001	.005	3	2
COAD	PINCR →	+0.470	+4.383	<.001	<.001	3	2
UCEC	TPM4P1 →	+0.222	+2.770	<.001	.003	3	2
UCEC	IQCF2 →	+0.225	+2.626	<.001	.006	3	2
UCEC	RNU6-33P →	+0.650	+2.860	.002	.004	3	2
UCEC	RNA5SP436 →	+0.636	+3.715	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 223 associations by consensus.

LINC01318 by IGHV3OR16-8 expression — HNSC

Explore this box plot interactively →