IGHV3OR16-8

Across TCGA pan-cancer cohorts, IGHV3OR16-8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IGHV3OR16-8’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3OR16-8 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3OR16-8 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHV3OR16-8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3OR16-8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−3.148	<.001	10	view →
LUAD	Female	All	+1.403	<.001	8	view →
KIRC	Male	All	+0.674	<.001	6	view →
BRCA	Female	All	−0.443	.001	6	view →
READ	All	All	−1.993	<.001	3	view →
ESCA	All	II,III,IV	+1.975	.035	2	view →
UCEC	All	IV	−0.440	.031	2	view →
STAD	Male	IV	−3.849	.028	1	view →
HNSC	All	III,IV	+0.578	.023	1	view →
LIHC	Male	All	−0.286	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IGHV3OR16-8–COAD

Open the COAD breakdown →