IGHV3OR16-8

Across TCGA pan-cancer cohorts, IGHV3OR16-8 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated IGHV3OR16-8 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3OR16-8 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV3OR16-8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGHV3OR16-8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.725	0.597	<.001	144	view →
SKCM	OS	Median	All	0.417	0.275	<.001	118	view →
BRCA	DFS	Median	All	0.969	0.928	<.001	92	view →
CESC	DFS	Quartile	All	0.861	0.666	.002	36	view →
ACC	OS	Tertile	All	0.133	0.686	.004	36	view →
UCEC	OS	Median	III,IV	0.705	0.415	.005	34	view →
KICH	OS	Tertile	II,III,IV	0.197	0.877	.021	30	view →
LUAD	DFS	Quartile	II,III,IV	0.752	0.411	.003	30	view →
GBM	OS	Tertile	All	0.283	0.433	.009	27	view →
UVM	OS	Tertile	III,IV	0.104	0.813	.001	27	view →
CHOL	DFS	Quartile	All	0.892	0.280	.003	21	view →
COAD	DFS	Median	II,III,IV	0.723	0.605	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

IGHV3OR16-8–HNSC (OS)

Open the HNSC breakdown →