IGHV3-60

Across TCGA patient cohorts, IGHV3-60 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,036 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3-60-associated GO terms across cancer lineages are Complement activation, B cell receptor signaling pathway, and Complement activation, classical pathway. Each is linked with IGHV3-60 in more than 29 cancer types. Because this analysis shows association rather than direction, both IGHV3-60-to-partner and partner-to-IGHV3-60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Complement activation grouped by IGHV3-60-low versus IGHV3-60-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-60→partner) and Y-score (partner→IGHV3-60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Complement activation →	+0.157	+1.181	<.001	<.001	3	30
CHOL	B cell receptor signaling pathway →	+0.118	+1.763	<.001	<.001	3	29
THCA	Complement activation, classical pathway →	+0.201	+1.230	<.001	<.001	3	29
THCA	Antimicrobial humoral response →	+0.108	+1.250	<.001	<.001	3	29
THCA	Antibacterial humoral response →	+0.168	+1.295	<.001	<.001	3	29
THCA	Humoral immune response mediated by circulating immunoglobulin →	+0.165	+1.203	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,036 associations by consensus.

Complement activation by IGHV3-60 expression — THCA

Explore this box plot interactively →