IGHV3-60

Across TCGA pan-cancer cohorts, IGHV3-60 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IGHV3-60’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-60 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-60 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGHV3-60 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-60 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−1.551	<.001	9	view →
LUAD	Male	All	+1.258	<.001	7	view →
BRCA	Female	II,III,IV	−0.463	<.001	6	view →
READ	All	All	−2.213	<.001	5	view →
KIRC	All	All	+0.388	<.001	4	view →
STAD	All	IV	−2.756	.013	2	view →
ESCA	All	II,III,IV	+1.654	.024	2	view →
LIHC	Male	All	−0.290	.007	2	view →
HNSC	All	III,IV	+0.658	.019	1	view →
LUSC	All	All	+0.533	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IGHV3-60–COAD

Open the COAD breakdown →