IGHV3-60

Across TCGA pan-cancer cohorts, IGHV3-60 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGHV3-60 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-60 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-60 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where IGHV3-60 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.671	0.536	<.001	143	view →
BRCA	DFS	Tertile	All	0.532	0.469	<.001	90	view →
SKCM	OS	Median	II,III,IV	0.823	0.629	.001	66	view →
OV	DFS	Tertile	All	0.450	0.345	.002	64	view →
UCEC	OS	Tertile	III,IV	0.752	0.486	.015	48	view →
KICH	DFS	Tertile	III,IV	0.025	0.773	<.001	33	view →
CHOL	DFS	Quartile	All	0.801	0.284	.012	33	view →
UVM	OS	Tertile	III,IV	0.104	0.813	.001	27	view →
DLBC	DFS	Quartile	III,IV	0.074	0.984	.008	24	view →
KIRP	DFS	Median	All	0.540	0.897	<.001	24	view →
MESO	OS	Quartile	III,IV	0.776	0.514	.011	18	view →
LUSC	OS	Median	II,III,IV	0.529	0.791	.007	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGHV3-60–HNSC (DFS)

Open the HNSC breakdown →