IGHV3-50

Across TCGA patient cohorts, IGHV3-50 RNA expression is significantly associated with the RNA expression of many other genes, with 5,625 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible IGHV3-50-associated genes across cancer lineages are IGKV1OR2-9, IGKV1D-33, and IGHV3OR16-11. Each is linked with IGHV3-50 in more than 28 cancer types. Because this analysis shows association rather than direction, both IGHV3-50-to-partner and partner-to-IGHV3-50 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV3-50 versus IGKV1OR2-9 in THCA, with a Pearson correlation of 0.79.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-50→partner) and Y-score (partner→IGHV3-50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	IGKV1OR2-9 →	+1.025	+0.438	<.001	<.001	3	29
CHOL	IGKV1D-33 →	+2.316	+0.548	<.001	<.001	3	29
LUSC	IGHV3OR16-11 →	+1.143	+0.770	<.001	<.001	3	28
LUSC	IGHV3OR16-12 →	+1.204	+0.688	<.001	<.001	3	28
THCA	IGHV3OR16-8 →	+1.934	+0.310	<.001	<.001	3	28
STAD	IGHV4OR15-8 →	+1.068	+0.413	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,625 associations by consensus.

IGHV3-50 vs IGKV1OR2-9 — THCA

Explore this scatter interactively →