IGHV3-50

Across TCGA pan-cancer cohorts, IGHV3-50 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated IGHV3-50 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher IGHV3-50 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHV3-50 expression acts as an unfavorable survival marker, although some lineages such as HNSC and STAD show a favorable association.

KIRP, HNSC, and GBM are the cancer types where IGHV3-50 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.440	0.836	<.001	84	view →
HNSC	DFS	Quartile	All	0.833	0.666	.001	50	view →
GBM	OS	Tertile	All	0.030	0.416	<.001	36	view →
STAD	OS	Median	IV	0.582	0.152	<.001	33	view →
MESO	DFS	Tertile	All	0.164	0.503	.013	27	view →
CESC	OS	Quartile	All	0.890	0.759	.014	12	view →
SKCM	DFS	Tertile	All	0.844	0.713	.012	11	view →
BRCA	OS	Quartile	All	0.981	0.957	.013	10	view →
UVM	OS	Tertile	All	0.315	0.711	.049	9	view →
THCA	OS	Tertile	IV	0.751	1.000	.014	9	view →
TGCT	DFS	Tertile	All	0.936	0.777	.016	8	view →
OV	OS	Tertile	II,III,IV	0.763	0.855	.045	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

IGHV3-50–KIRP (DFS)

Open the KIRP breakdown →