IGHV3-50

Across TCGA pan-cancer cohorts, IGHV3-50 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of IGHV3-50’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHV3-50 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHV3-50 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

LUAD, COAD, and STAD are the cancer types where IGHV3-50 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-50 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.585	<.001	10	view →
COAD	Female	All	−0.812	<.001	8	view →
STAD	Male	All	−0.537	.022	5	view →
KIRC	All	All	+0.142	.003	5	view →
READ	All	All	−0.700	<.001	3	view →
KICH	Male	All	−0.075	.034	3	view →
LIHC	Male	All	−0.076	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

IGHV3-50–LUAD

Open the LUAD breakdown →