Across TCGA patient cohorts, IGHV3-38 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,111 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3-38-associated GO terms across cancer lineages are B cell mediated immunity, B cell receptor signaling pathway, and Regulation of B cell activation. Each is linked with IGHV3-38 in more than 29 cancer types. Because this analysis shows association rather than direction, both IGHV3-38-to-partner and partner-to-IGHV3-38 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-38→partner) and Y-score (partner→IGHV3-38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	B cell mediated immunity →	+0.104	+0.995	<.001	<.001	3	30
CHOL	B cell receptor signaling pathway →	+0.103	+1.432	<.001	.002	3	29
CHOL	Regulation of B cell activation →	+0.060	+1.155	<.001	.001	3	28
CHOL	Positive regulation of respiratory burst →	+0.176	+0.985	<.001	<.001	3	28
CHOL	Regulation of B cell differentiation →	+0.080	+1.424	<.001	.002	3	28
THCA	Antibacterial humoral response →	+0.170	+1.393	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,111 associations by consensus.

Exploration

IGHV3-38 survival (RNA) · tumor vs normal (RNA) · all IGHV3-38 data types