Across TCGA patient cohorts, IGHV3-38 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV3-38-associated genes across cancer lineages are PRAMEF28P, RNU6-1252P, and MIR425. Each is linked with IGHV3-38 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-38-to-partner and partner-to-IGHV3-38 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-38→partner) and Y-score (partner→IGHV3-38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAMEF28P →	+0.071	+3.814	.004	.002	3	2
COAD	RNU6-1252P →	+0.526	+7.741	<.001	.009	3	2
UCEC	MIR425 →	+0.477	+2.914	.004	.008	3	2
BLCA	FGF7P1 →	+0.189	+7.640	<.001	.009	3	1
UCEC	SPDYE20P →	+0.453	+4.206	<.001	<.001	3	1
BLCA	RNA5SP258 →	+0.388	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Exploration

IGHV3-38 survival (RNA) · tumor vs normal (RNA) · all IGHV3-38 data types