IGHV3-30

Across TCGA patient cohorts, IGHV3-30 protein abundance is significantly associated with the RNA expression of many other genes, with 5,229 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGHV3-30-associated genes across cancer lineages are IGKV1-27, PPP1R16B, and LYVE1. Each is linked with IGHV3-30 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGHV3-30-to-partner and partner-to-IGHV3-30 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV3-30 versus IGKV1-27 in OV, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-30→partner) and Y-score (partner→IGHV3-30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IGKV1-27 →	+2.729	+1.230	<.001	.004	3	4
LSCC	PPP1R16B →	+0.637	+0.907	<.001	<.001	3	3
GBM	LYVE1 →	+1.910	+0.633	<.001	<.001	3	3
LSCC	CD79B →	+0.602	+0.852	<.001	<.001	3	3
LSCC	TBX21 →	+0.489	+0.804	<.001	.001	3	3
LSCC	IGHJ2P →	+1.256	+1.087	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,229 associations by consensus.

IGHV3-30 vs IGKV1-27 — OV

Explore this scatter interactively →