IGHV3-30

Across TCGA pan-cancer cohorts, IGHV3-30 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated IGHV3-30 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-30 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-30 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UCEC are the cancer types where IGHV3-30 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.761	0.630	<.001	144	view →
SKCM	OS	Median	All	0.407	0.278	<.001	133	view →
UCEC	DFS	Quartile	III,IV	0.651	0.327	<.001	56	view →
BRCA	DFS	Median	III,IV	0.622	0.359	.004	39	view →
LIHC	DFS	Median	II,III,IV	0.527	0.327	<.001	38	view →
LUAD	DFS	Tertile	II,III,IV	0.618	0.310	.002	28	view →
CHOL	DFS	Median	All	0.627	0.192	.005	24	view →
SARC	OS	Median	All	0.893	0.782	.006	22	view →
MESO	OS	Median	All	0.690	0.327	.019	22	view →
OV	DFS	Tertile	All	0.434	0.349	.017	20	view →
KIRC	OS	Median	All	0.767	0.842	.009	20	view →
GBM	OS	Median	All	0.305	0.527	.005	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

IGHV3-30–HNSC (DFS)

Open the HNSC breakdown →