IGHV3-30

Across TCGA pan-cancer cohorts, IGHV3-30 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGHV3-30’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3-30 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3-30 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, KIRC, and LUAD are the cancer types where IGHV3-30 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3-30 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.770	<.001	9	view →
KIRC	Male	All	+2.112	<.001	8	view →
LUAD	Female	All	+2.032	<.001	7	view →
READ	All	All	−2.903	.003	2	view →
LIHC	Male	All	−2.458	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IGHV3-30–COAD

Open the COAD breakdown →