IGHV3-30

Across TCGA patient cohorts, IGHV3-30 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV3-30-associated genes across cancer lineages are H2BC2P, OR4C15, and RNA5SP327. Each is linked with IGHV3-30 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-30-to-partner and partner-to-IGHV3-30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC2P grouped by IGHV3-30-low versus IGHV3-30-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-30→partner) and Y-score (partner→IGHV3-30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	H2BC2P →	+0.088	+4.469	<.001	.006	3	1
SKCM	OR4C15 →	+0.038	+4.328	<.001	.007	3	1
SKCM	RNA5SP327 →	+0.384	+3.766	<.001	.005	3	1
SKCM	SNORA80C →	+0.535	+3.980	<.001	.003	3	1
SKCM	RNU6-142P →	+0.450	+3.923	<.001	.003	3	1
SKCM	RNU1-8P →	+0.313	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

H2BC2P by IGHV3-30 expression — SKCM

Explore this box plot interactively →